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A One-Pot Multicomponent 1,3-Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Dihydrothiophenone-Engrafted Dispiro Hybrid Heterocycles
Journal article   Peer reviewed

A One-Pot Multicomponent 1,3-Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Dihydrothiophenone-Engrafted Dispiro Hybrid Heterocycles

Mani Anusha Rani, Sundaravel Vivek Kumar, Karuppiah Malathi, Muthumani Muthu, Abdulrahman I Almansour, Raju Suresh Kumar and Raju Ranjith Kumar
ACS combinatorial science, Vol.19(5), pp.308-314
08/05/2017
DOI: https://doi.org/10.1021/acscombsci.6b00186
PMID: 28371579

Abstract

Combinatorial Chemistry Techniques Cycloaddition Reaction Heterocyclic Compounds, Fused-Ring - chemical synthesis Humans Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Small Molecule Libraries - chemical synthesis Spiro Compounds - chemical synthesis Stereoisomerism Structure-Activity Relationship Thiophenes - chemical synthesis
The combinatorial syntheses of a library of novel dihydrothiophenone-engrafted dispiro oxindole/indenoquinoxaline-pyrrolidine/pyrrolothiazole/indolizine hybrid heterocycles have been realized through a chemo-, regio-, and stereoselective multicomponent 1,3-dipolar cycloaddition strategy.

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