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A One-Pot Synthesis of trans-N-Alkylaziridine-2-carboxylates from Amino Alcohol Esters
Journal article   Peer reviewed

A One-Pot Synthesis of trans-N-Alkylaziridine-2-carboxylates from Amino Alcohol Esters

Amani Kaabi, Brahim Ould Elemine and Rafâa Besbes
Synthetic communications, Vol.41(10), pp.1472-1480
19/04/2011
DOI: https://doi.org/10.1080/00397911.2010.486512

Abstract

Amino alcohols mono and diesters methanesulfonyl chloride trans-N-alkylaziridine-2-carboxylates
A series of new trans-N-alkylaziridine-2-carboxylates 3 was conveniently synthesized in a one-pot reaction by treatment of 1,2-amino alcohol mono and diesters 1 with methanesulfonyl chloride in the presence of (iPr) 2 NEt. The products were obtained in good to excellent yields with high trans-selectivity.

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