Abstract
To find out the effect of [Cu (I)-(nicotinic acid)2]1Cl-complex (Cu-N complex) on aluminum induced Alzheimer's disease in Wistarrats, memory impairment was induced by aluminum chloride, (10 mg/kg bwi.p.) for 30 d. To study the activity of (Cu-N complex) (400 mu g/kg B.W.), Wistar rats were administered for 30 d along with aluminum chloride. Biochemical parameters of oxidative stress were estimated in brain after the treatment. The major finding of this study is that aluminum enhanced oxidative stress. Cu-N complex showed a significant improvement in increasing of TAC and reduction of the oxidative stress by reduction of MPO, AchE and NO, in the histopathological investigation, it restoreshipocummal neuron to normal status and there was a decreased in DNA damage in the treatment group. The present study clearly demonstrated the beneficial effects of (Cu-N complex) that shows good antioxidant properties, and may act as a key to treat Alzheimer's disease.