Abstract
We have witnessed the impact of ML in disease diagnosis, image recognition and classification, and many more related fields. Healthcare is a sensitive field related to people's lives in which decisions need to be carefully taken based on solid evidence. However, most ML models are complex, i.e., black-box, meaning they do not provide insights into how the problems are solved or why such decisions are proposed. This lack of interpretability is the main reason why some ML models are not widely used yet in real environments such as healthcare. Therefore, it would be beneficial if ML models could provide explanations allowing physicians to make data-driven decisions that lead to higher quality service. Recently, several efforts have been made in proposing interpretable machine learning models to become more convenient and applicable in real environments. This paper aims to provide a comprehensive survey and symmetry phenomena of IML models and their applications in healthcare. The fundamental characteristics, theoretical underpinnings needed to develop IML, and taxonomy for IML are presented. Several examples of how they are applied in healthcare are investigated to encourage and facilitate the use of IML models in healthcare. Furthermore, current limitations, challenges, and future directions that might impact applying ML in healthcare are addressed.