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A SIMPLE AND CONVENIENT HIGH YIELDING SYNTHESIS OF SUBSTITUTED ISOINDOLINES
Journal article   Peer reviewed

A SIMPLE AND CONVENIENT HIGH YIELDING SYNTHESIS OF SUBSTITUTED ISOINDOLINES

Keith Smith, Gamal A. El-Hiti, Amany S. Hegazy and Ahmed Fekri
Heterocycles, Vol.80(2), pp.941-956
01/03/2010
DOI: https://doi.org/10.3987/COM-09-S(S)61

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Trifluoroacetic anhydride-induced dehydration of substituted 2-(pivaloylaminomethyl)phenyl- and 2-(dimethylaminocarbonylmethyl)phenyl-methanols gives the corresponding isoindolines in excellent yields when there are aryl substituents at the methanol carbon atom.

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