Abstract
The main object of this paper is to investigate the existence of solutions for a self-adjoint coupled system of nonlinear second-order ordinary differential equations equipped with nonlocal multi-point coupled boundary conditions on an arbitrary domain. We apply the Leray-Schauder alternative, the Schauder fixed point theorem and the Banach contraction mapping principle in order to derive the main results, which are then well-illustrated with the aid of several examples. Some potential directions for related further researches are also indicated.