Abstract
Acrylamide (AA) is neurotoxic to experimental animals and humans. Also, it has mutagenic and carcinogenic effects. This study was carried out to investigate the effects of green tea extract on liver function test in male rats received different doses of acrylamide. Animals were assigned at random to six groups: group 1 served as control, while groups 2, 3 were received 7, 14 mg/100g B.W /day of acrylamide, respectively in drinking water for 15 and 30 days. Group 4 received green tea 1.5% concentration and groups 5, 6 received 7, 14 mg/100 g B.W /day of acrylamide in a combination with green tea for 15 and 30 days. Aspartate amintransferase (AST), and Alanine aminotransferase (ALT) and Alkaline phosphates (ALP), significantly increased whereas cholinesterase activity declined significantly in rats received AA in both concentrations and time in comparison with the control. However, the values of cholinesterase activity decreased when rats received green tea alone or in combination with AA. [Thanaa A. El-Kholy, Nahlaa A. Khalifa, A. K. Alghamidi, and Arwa M. Badereldin. A Trail of Using Green Tea for Competing Toxicity of Acrylamide on Liver Function. Life Sci J 2012;9(4):3690-3695]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 547