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A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions
Journal article   Peer reviewed

A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions

Kristian Rahbek Knudsen and Karl Anker Jorgensen
Organic & biomolecular chemistry, Vol.3(8), pp.1362-1364
21/04/2005
DOI: https://doi.org/10.1039/b500618j
PMID: 15827627

Abstract

Aza Compounds - chemical synthesis Aza Compounds - chemistry Molecular Structure Stereoisomerism
An approach to asymmetric catalysis based on chiral molecular recognition by the combination of chiral Lewis acids and chiral organocatalysis for the formation of optically active quarternary centers in the aza-Henry reaction is presented; this procedure leads to products with up to 98% ee and a diastereomeric ratio of 14 : 1 in excellent yields with catalyst loadings of 5 mol%.

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