Abstract
Developing cost-effective approaches for the fabrication of electrochemical devices is instantly needed for transferring from basic research to point-care technology. Herein, we report an electrochemical sensing platform based on an iron molybdate (Fe-2(MoO4)(3))-modified screen-printed carbon electrode (SPCE) for the sensitive and selective sensing of dopamine (DA). The formation and purity of Fe-2(MoO4)(3) was characterized via multiple spectroscopic techniques. Likewise, the electrochemical performance of the Fe-2(MoO4)(3) modified SPCE was probed via cyclic voltammetry and differential pulse voltammetry. Fe-2(MoO4)(3)/SPCE exhibited a 1.44-fold increase in electrochemical sensing activity towards DA than bare SPCE. In a range as wide as from 0.01 to 225 mu M, a linear relationship is well established with the value of correlation coefficient being 0.9914. The limit of detection (S/N = 3) is well defined as 0.002 mu M, which is lower than that reported previously. The fabricated Fe-2(MoO4)(3)/SPCE shows good anti-interference ability towards DA detection in the presence of numerous co-interfering compounds at a higher level. Moreover, a biological analysis indicated that spiked DA can be determined accurately by Fe-2(MoO4)(3) modified SPCE with the recovery rate in the range of 99.30-99.80% in human serum samples. Based on the above-mentioned results, the proposed electrochemical sensor has great potential in the fields of biological detection.