Abstract
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A convenient preparation of the (
R)- and (
S)-enantiomers of
O-(4-methoxyphenyl)-glycidol by a one-pot reduction of ketone
3 and in situ lipase mediated resolution is described. Activated moist aluminium oxide in the presence of
Pseudomonas cepacia lipase immobilized on ceramic particles (PS-C) has been found effective for the transesterification leading to a high degree of enantioselectivity. These chiral glycidols were further used as a chiral precursor for the synthesis of biologically important 1,2-
O-diacyl-
sn-glycerol under mild reaction conditions. The present method is facile for the synthesis of chiral glycidols in high enantioselectivity when compared to the previously reported methods.