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A facile ionic liquid promoted synthesis, cholinesterase inhibitory activity and molecular modeling study of novel highly functionalized spiropyrrolidines
Journal article   Open access  Peer reviewed

A facile ionic liquid promoted synthesis, cholinesterase inhibitory activity and molecular modeling study of novel highly functionalized spiropyrrolidines

Abdulrahman I Almansour, Raju Suresh Kumar, Natarajan Arumugam, Alireza Basiri, Yalda Kia, Mohamed Ashraf Ali, Mehvish Farooq and Vikneswaran Murugaiyah
Molecules (Basel, Switzerland), Vol.20(2), pp.2296-2309
29/01/2015
DOI: https://doi.org/10.3390/molecules20022296
PMCID: PMC6272427
PMID: 25642838

Abstract

Acetylcholinesterase - chemistry Catalytic Domain Cholinesterase Inhibitors - chemical synthesis Cycloaddition Reaction Ionic Liquids - chemistry Models, Molecular Molecular Docking Simulation Pyrrolidines - chemical synthesis Spiro Compounds - chemical synthesis
A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 µM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor.
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https://doi.org/10.3390/molecules20022296View
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