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A facile one-pot synthesis of novel 2,5-disubstituted-1,3,4-oxadiazoles under conventional and microwave conditions and evaluation of their in vitro antimicrobial activities
Journal article   Open access  Peer reviewed

A facile one-pot synthesis of novel 2,5-disubstituted-1,3,4-oxadiazoles under conventional and microwave conditions and evaluation of their in vitro antimicrobial activities

Nida N. Farshori, Abdul Rauf, Maqsood A. Siddiqui, Ebtesam S. Al-Sheddi and Mai M. Al-Oqail
Arabian journal of chemistry, Vol.10(S2), pp.S2853-S2861
05/2017
DOI: https://doi.org/10.1016/j.arabjc.2013.11.010

Abstract

2,5-Disubstituted-1,3,4-oxadiazoles Antimicrobial activities Conventional and microwave synthesis Spectral data
A rapid and efficient solvent-free synthesis of 2,5-disubstituted-1,3,4-oxadiazoles (3a–l) from fatty acid hydrazides (1a–f) under microwave irradiation is described. The structural elucidation of these compounds is based on their spectral data (IR, 1H NMR, 13C NMR and MS). All the newly synthesized compounds have been screened for their antibacterial and antifungal activities. The compounds 3f, 3j and 3l were found to be most potent anti-microbial agents.
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https://doi.org/10.1016/j.arabjc.2013.11.010View
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