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A facile regio- and stereoselective synthesis of novel dispirooxindolyl-[acridine-2 ',3-pyrrolidine/thiapyrrolizidine]-1 '-ones via 1,3-dipolar cycloaddition of azomethine ylides
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A facile regio- and stereoselective synthesis of novel dispirooxindolyl-[acridine-2 ',3-pyrrolidine/thiapyrrolizidine]-1 '-ones via 1,3-dipolar cycloaddition of azomethine ylides

Shanmugavel Uma Maheswari, Subbu Perumal and Abdulrahman I. Almansour
Tetrahedron letters, Vol.53(3), pp.349-353
18/01/2012
DOI: https://doi.org/10.1016/j.tetlet.2011.11.048

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A facile regio- and stereoselective synthesis of novel dispirooxindolyl-[acridine-2',3-pyrrolidine]-1'-ones and dispirooxindolyl-[acridine-2',3-thiapyrrolizidine]-1'-ones have been accomplished via 1,3-dipolar cycloaddition of azomethine ylides, generated in situ from the reaction of sarcosine/1,3-thiazolane-4-carboxylic acid and substituted isatins, to a series of (E)-2-[arylmethylidene]-3,4-dihydro-1(2H)-acridinones in good yields. (C) 2011 Elsevier Ltd. All rights reserved.

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