A facile synthesis of novel unsymmetrical N-(4-oxo-2-phenyl-3(4 H)-quinazolinoyl)- N-(aryl)acetamidines

Rasool Khan; Mohammad Arfan; Javeed Mahmood; Shazia Anjum; M. Iqbal Choudhary

doi:10.1016/j.cclet.2010.04.009

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A facile synthesis of novel unsymmetrical N-(4-oxo-2-phenyl-3(4 H)-quinazolinoyl)- N-(aryl)acetamidines

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A facile synthesis of novel unsymmetrical N-(4-oxo-2-phenyl-3(4 H)-quinazolinoyl)- N-(aryl)acetamidines

Rasool Khan, Mohammad Arfan, Javeed Mahmood, Shazia Anjum and M. Iqbal Choudhary

Chinese chemical letters, Vol.21(8), pp.905-910

01/08/2010

DOI: https://doi.org/10.1016/j.cclet.2010.04.009

Abstract

3-Amino-2-phenyl-4(3 H)-quinazolinone

Triethylorthoacetate

Unsymmetrical N-(4-oxo-2-phenyl-3(4 H)-quinazolinoyl)- N-(aryl)acetamidines

A series of novel unsymmetrical N-(4-oxo-2-phenyl-3(4 H)-quinazolinoyl)- N-(aryl)acetamidines was synthesized by reacting ethyl(1 E)- N-(4-oxo-2-phenylquinazolin-3(4 H)-yl)ethanimidoate ( 2) and suitable reactive aromatic amines. Structures’ determination of the synthesized compounds was carried out using spectroscopic techniques including IR, 1H NMR, and mass spectrometry. Structural effects on reactivity were also studied.

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Title: A facile synthesis of novel unsymmetrical N-(4-oxo-2-phenyl-3(4 H)-quinazolinoyl)- N-(aryl)acetamidines
Creators - without role: Rasool Khan - Abdul Wali Khan University Mardan
Mohammad Arfan - University of Peshawar
Javeed Mahmood - University of Peshawar
Shazia Anjum - University of Saskatchewan
M. Iqbal Choudhary - University of Karachi
Publication Details: Chinese chemical letters, Vol.21(8), pp.905-910
Publisher: Elsevier B.V
Identifiers: 9941252008331
Academic Unit: King Abdullah University of Science & Technology; King Abdulaziz University
Language: English
Resource Type: Journal article