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A facile synthesis of quinazolino[1,4] benzodiazepine alkaloids via reductive N-heterocyclization of N-(2-nitrobenzoyl)amides: Total synthesis of asperlicin C, circumdatin H, and analogues
Journal article   Open access  Peer reviewed

A facile synthesis of quinazolino[1,4] benzodiazepine alkaloids via reductive N-heterocyclization of N-(2-nitrobenzoyl)amides: Total synthesis of asperlicin C, circumdatin H, and analogues

Naim H. Al-Said, Khaled Q. Shawakfeh, Mohammad I. Ibrahim and Sami H. Tayyem
ARKIVOC free online journal of organic chemistry, Vol.2010(9), pp.282-292
11/07/2010
DOI: https://doi.org/10.3998/ark.5550190.0011.926

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A facile and short synthesis of a series of quinazolino[1,4]benzodiazepine alkaloids, including asperlicin C, circumdatin H and some analogues, is reported utilizing coupling of readily available [1,4] benzodiazepine with 2-nitrobenzoyl chlorides, followed by a reductive N-heterocyclization.
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https://doi.org/10.3998/ark.5550190.0011.926View
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