Abstract
An expedient, three-component, [3+2]-cycloaddition/annulation domino protocol for the synthesis of a series of cage penta- and hexacyclic compounds in good to excellent yields is described. The ring systems thus generated contain as structural elements bridged, fused and spiro rings and were obtained with complete selectivity through the creation of two C–C and two C–N bonds, which led to the generation of two azaheterocyclic rings, four carbon and one nitrogen adjacent stereocentres, three of which are quaternary.
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