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A general method for the n-alkylation of thioamides
Journal article   Peer reviewed

A general method for the n-alkylation of thioamides

Alan R. Katritzky and Malgorzata Drewniak
Tetrahedron letters, Vol.29(15), pp.1755-1758
1988

Abstract

Thioamides are N-alkylated in a two-step procedure: (i) Reaction with an aldehyde and benzotriazole yields an adduct which is (ii) reduced to the N-alkylthiomide by NaBH 4. Graphic

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