A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

David A van Heel; Lude Franke; Karen A Hunt; Rhian Gwilliam; Alexandra Zhernakova; Mike Inouye; Martin C Wapenaar; Martin C N M Barnardo; Graeme Bethel; Geoffrey K T Holmes; Con Feighery; Derek Jewell; Dermot Kelleher; Parveen Kumar; Simon Travis; Julian RF Walters; David S Sanders; Peter Howdle; Jill Swift; Raymond J Playford; William M McLaren; M Luisa Mearin; Chris J Mulder; Ross McManus; Ralph McGinnis; Lon R Cardon; Panos Deloukas; Cisca Wijmenga

doi:10.1038/ng2058

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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

Journal article

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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

David A van Heel, Lude Franke, Karen A Hunt, Rhian Gwilliam, Alexandra Zhernakova, Mike Inouye, Martin C Wapenaar, Martin C N M Barnardo, Graeme Bethel, Geoffrey K T Holmes, …

Nature genetics, Vol.39(7), pp.827-829

01/07/2007

DOI: https://doi.org/10.1038/ng2058

PMCID: PMC2274985

PMID: 17558408

Abstract

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 × 10−7) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5′ of IL21; meta-analysis P = 1.3 × 10−14, odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.

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Title: A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
Creators - without role: David A van Heel - Queen Mary University of London
Lude Franke - University Medical Center Utrecht
Karen A Hunt - Queen Mary University of London
Rhian Gwilliam - Wellcome Sanger Institute
Alexandra Zhernakova - University Medical Center Utrecht
Mike Inouye - Wellcome Sanger Institute
Martin C Wapenaar - University Medical Center Groningen
Martin C N M Barnardo - Churchill Hospital
Graeme Bethel - Wellcome Sanger Institute
Geoffrey K T Holmes - Department of Gastroenterology, Derbyshire Royal Infirmary
Con Feighery - Trinity College Dublin
Derek Jewell - University of Oxford
Dermot Kelleher - Trinity College Dublin
Parveen Kumar - Queen Mary University of London
Simon Travis - University of Oxford
Julian RF Walters - Hammersmith Hospital
David S Sanders - Royal Hallamshire Hospital
Peter Howdle - St James's University Hospital
Jill Swift - University Hospital Llandough
Raymond J Playford - Queen Mary University of London
William M McLaren - Wellcome Sanger Institute
M Luisa Mearin - Leiden University Medical Center
Chris J Mulder - Vrije Universiteit Amsterdam
Ross McManus - Trinity College Dublin
Ralph McGinnis - Wellcome Sanger Institute
Lon R Cardon - Wellcome Centre for Human Genetics
Panos Deloukas - Wellcome Sanger Institute
Cisca Wijmenga - University Medical Center Utrecht
Publication Details: Nature genetics, Vol.39(7), pp.827-829
Identifiers: 9935755308331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article