A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

John F. Peden; Jemma C. Hopewell; Danish Saleheen; John C. Chambers; Jorg Hager; Nicole Soranzo; Rory Collins; John Danesh; Paul Elliott; Martin Farrall; Kathy Stirrups; Weihua Zhang; Anders Hamsten; Sarah Parish; Mark Lathrop; Hugh Watkins; Robert Clarke; Panos Deloukas; Jaspal S. Kooner; Anuj Goel; Halit Ongen; Rona J. Strawbridge; Simon Heath; Anders Malarstig; Anna Helgadottir; John Ohrvik; Muhammed Murtaza; Simon Potter; Sarah E. Hunt; Marc Delepine; Shapour Jalilzadeh; Tomas Axelsson; Ann-Christine Syvanen; Rhian Gwilliam; Suzannah Bumpstead; Emma Gray; Sarah Edkins; Lasse Folkersen; Theodosios Kyriakou; Anders Franco-Cereceda; Anders Gabrielsen; Udo Seedorf; Per Eriksson; Alison Offer; Louise Bowman; Peter Sleight; Jane Armitage; Richard Peto; Goncalo Abecasis; Nabeel Ahmed; Mark Caulfield; Peter Donnelly; Philippe Froguel; Angad S. Kooner; Mark I. McCarthy; Nilesh J. Samani; James Scott; Joban Sehmi; Angela Silveira; Mai-Lis Hellenius; Ferdinand M. van't Hooft; Gunnar Olsson; Stephan Rust; Gerd Assmann; Simona Barlera; Gianni Tognoni; Maria Grazia Franzosi; Pamela Linksted; Fiona R. Green; Asif Rasheed; Moazzam Zaidi; Nabi Shah; Maria Samuel; Nadeem H. Mallick; Muhammad Azhar; Khan S. Zaman; Abdus Samad; Mohammad Ishaq; Ali R. Gardezi; Fazal-ur-Rehman Memon; Philippe M. Frossard; Tim Spector; Leena Peltonen; Markku S. Nieminen; Juha Sinisalo; Veikko Salomaa; Samuli Ripatti; Derrick Bennett; Karin Leander; Bruna Gigante; Ulf de Faire; Silvia Pietri; Francesca Gori; Roberto Marchioli; Suthesh Sivapalaratnam; John J. P. Kastelein; Mieke D. Trip; Eirini V. Theodoraki; George V. Dedoussis; Jamie C. Engert; Salim Yusuf; Sonia S. Anand; Coronary Artery Dis C4D Genetics C

doi:10.1038/ng.782

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A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

Journal article

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A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

John F. Peden, Jemma C. Hopewell, Danish Saleheen, John C. Chambers, Jorg Hager, Nicole Soranzo, Rory Collins, John Danesh, Paul Elliott, Martin Farrall, …

Nature genetics, Vol.43(4), pp.339-U89

01/04/2011

DOI: https://doi.org/10.1038/ng.782

PMID: 21378988

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with similar to 575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 x 10(-8) in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.

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Title: A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
Creators - without role: John F. Peden - University of Oxford
Jemma C. Hopewell - University of Oxford
Danish Saleheen - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
John C. Chambers - University of London
Jorg Hager - Evry
Nicole Soranzo - Wellcome Sanger Institute
Rory Collins - University of Oxford
John Danesh - University of Cambridge
Paul Elliott - University of London
Martin Farrall - University of Oxford
Kathy Stirrups - Wellcome Sanger Institute
Weihua Zhang - University of London
Anders Hamsten - Karolinska Institutet
Sarah Parish - University of Oxford
Mark Lathrop - Evry
Hugh Watkins - University of Oxford
Robert Clarke - University of Oxford
Panos Deloukas - Wellcome Sanger Institute
Jaspal S. Kooner - Ealing Hosp Natl Hlth Serv NHS Trust, Southall, Middx, England
Anuj Goel - University of Oxford
Halit Ongen - University of Oxford
Rona J. Strawbridge - Karolinska Institutet
Simon Heath - Evry
Anders Malarstig - Karolinska Institutet
Anna Helgadottir - University of Oxford
John Ohrvik - Karolinska Institutet
Muhammed Murtaza - Wellcome Sanger Institute
Simon Potter - Wellcome Sanger Institute
Sarah E. Hunt - Wellcome Sanger Institute
Marc Delepine - Evry
Shapour Jalilzadeh - University of Oxford
Tomas Axelsson - Uppsala University
Ann-Christine Syvanen - Uppsala University
Rhian Gwilliam - Wellcome Sanger Institute
Suzannah Bumpstead - Wellcome Sanger Institute
Emma Gray - Wellcome Sanger Institute
Sarah Edkins - Wellcome Sanger Institute
Lasse Folkersen - Karolinska Institutet
Theodosios Kyriakou - University of Oxford
Anders Franco-Cereceda - Karolinska Institutet
Anders Gabrielsen - Karolinska Institutet
Udo Seedorf - University of Münster
Per Eriksson - Karolinska Institutet
Alison Offer - University of Oxford
Louise Bowman - University of Oxford
Peter Sleight - University of Oxford
Jane Armitage - University of Oxford
Richard Peto - University of Oxford
Goncalo Abecasis - Biostat
Nabeel Ahmed - Ealing Hosp NHS Trust, Southall, Middx, England
Mark Caulfield - Queen Mary University of London
Peter Donnelly - University of Oxford
Philippe Froguel
Angad S. Kooner - Ealing Hosp NHS Trust, Southall, Middx, England
Mark I. McCarthy - University of Oxford
Nilesh J. Samani - University of Leicester
James Scott - University of London
Joban Sehmi - University of London
Angela Silveira - Karolinska Institutet
Mai-Lis Hellenius - Karolinska Institutet
Ferdinand M. van't Hooft - Karolinska Institutet
Gunnar Olsson - College Station Medical Center
Stephan Rust - University of Münster
Gerd Assmann - University of Münster
Simona Barlera - Ist Ric Farmacol Mario Negri, Dept Cardiovasc Res, Milan, Italy
Gianni Tognoni - Mylan
Maria Grazia Franzosi - Mylan
Pamela Linksted - University of Oxford
Fiona R. Green - University of Surrey
Asif Rasheed - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Moazzam Zaidi - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Nabi Shah - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Maria Samuel - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Nadeem H. Mallick - Punjab Inst Cardiol, Dept Cardiol, Lahore, Pakistan
Muhammad Azhar - Punjab Inst Cardiol, Dept Cardiol, Lahore, Pakistan
Khan S. Zaman - Natl Inst Cardiovasc Dis, Dept Cardiol, Karachi, Pakistan
Abdus Samad - Federal Reserve
Mohammad Ishaq - Karachi Inst Heart Dis, Dept Cardiol, Fed B Area, Karachi, Pakistan
Ali R. Gardezi - Ch Pervaiz Elahi Inst Cardiol, Dept Cardiol, Multan, Pakistan
Fazal-ur-Rehman Memon - Red Crescent Inst Cardiol, Dept Cardiol, Hyderabad, Andhra Pradesh, Pakistan
Philippe M. Frossard - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Tim Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Leena Peltonen - Wellcome Sanger Institute
Markku S. Nieminen - University of Helsinki
Juha Sinisalo - Univ Cent Hosp, Cardiovasc Lab, Helsinki, Finland
Veikko Salomaa - Natl Inst Hlth & Welf, Helsinki, Finland
Samuli Ripatti - Natl Inst Hlth & Welf, Helsinki, Finland
Derrick Bennett - University of Oxford
Karin Leander - Karolinska Institutet
Bruna Gigante - Karolinska Institutet
Ulf de Faire - Karolinska Institutet
Silvia Pietri - Ist Ric Farmacol Mario Negri, Dept Cardiovasc Res, Milan, Italy
Francesca Gori - Mylan
Roberto Marchioli - Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, Lab Clin Epidemiol Cardiovasc Dis, I-66030 Santa Maria Imbaro, Italy
Suthesh Sivapalaratnam - University of Amsterdam
John J. P. Kastelein - University of Amsterdam
Mieke D. Trip - University of Amsterdam
Eirini V. Theodoraki - Harokopio University of Athens
George V. Dedoussis - Harokopio University of Athens
Jamie C. Engert - McGill University
Salim Yusuf - McMaster University
Sonia S. Anand - McMaster University
Coronary Artery Dis C4D Genetics C
Publication Details: Nature genetics, Vol.43(4), pp.339-U89
Publisher: Springer Nature
Number of pages: 8
Grant note: University of Cambridge, UK; University of Cambridge Health-F22008-200647 / European Commission (FAD); European Commission; European Commission Joint Research Centre Merck Co; Merck & Company SP/04/002 / British Heart Foundation 560283 / Stockholm County Council British Heart Foundation Aarno Koskelo Foundation Karolinska Institutet and Stockholm County Council UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) DASTI (Danish Agency for Science, Technology and Innovation) Finnish Foundation for Cardiovascular Research Oxford BHF Centre of Research Excellence RG/08/014/24067 / British Heart Foundation Knut and Alice Wallenberg Foundation; Knut & Alice Wallenberg Foundation AstraZeneca G0801056B; G0601966; G0801056; MC_U137686857; G0700931; G9521010 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Torsten and Ragnar Soderberg Foundation Centre for Non-Communicable Diseases, Pakistan Swedish Heart-Lung Foundation G0700931; G0601966 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Roche Vitamins Ltd. National Institute for Health Research Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust, Ealing Hospital NHS Trust Foundation for Strategic Research Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas G0601966; G0801056; G9521010; G0700931; MC_U137686857 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Oxford British Heart Foundation Centre of Research Excellence 075491/Z/04; 084723/Z/08/Z; 081917/Z/07/Z; 091746/Z/10/Z / Wellcome Trust RP-PG-0407-10371 / National Institute for Health Research; National Institutes of Health Research (NIHR) LSHM-CT-2007-037273 / European Community; European Commission
Identifiers: 9935858908331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article