A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Nicole Soranzo; Tim D. Spector; Massimo Mangino; Brigitte Kuehnel; Augusto Rendon; Alexander Teumer; Christina Willenborg; Benjamin Wright; Li Chen; Mingyao Li; Perttu Salo; Benjamin F. Voight; Philippa Burns; Roman A. Laskowski; Yali Xue; Stephan Menzel; David Altshuler; John R. Bradley; Suzannah Bumpstead; Mary-Susan Burnett; Joseph Devaney; Angela Doering; Roberto Elosua; Stephen E. Epstein; Wendy Erber; Mario Falchi; Stephen F. Garner; Mohammed J. R. Ghori; Alison H. Goodall; Rhian Gwilliam; Hakon H. Hakonarson; Alistair S. Hall; Naomi Hammond; Christian Hengstenberg; Thomas Illig; Inke R. Koenig; Christopher W. Knouff; Ruth McPherson; Olle Melander; Vincent Mooser; Matthias Nauck; Markku S. Nieminen; Christopher J. O'Donnell; Leena Peltonen; Simon C. Potter; Holger Prokisch; Daniel J. Rader; Catherine M. Rice; Robert Roberts; Veikko Salomaa; Jennifer Sambrook; Stefan Schreiber; Heribert Schunkert; Stephen M. Schwartz; Jovana Serbanovic-Canic; Juha Sinisalo; David S. Siscovick; Klaus Stark; Ida Surakka; Jonathan Stephens; John R. Thompson; Uwe Voelker; Henry Voelzke; Nicholas A. Watkins; George A. Wells; H-Erich Wichmann; David A. Van Heel; Chris Tyler-Smith; Swee Lay Thein; Sekar Kathiresan; Markus Perola; Muredach P. Reilly; Alexandre F. R. Stewart; Jeanette Erdmann; Nilesh J. Samani; Christa Meisinger; Andreas Greinacher; Panos Deloukas; Willem H. Ouwehand; Christian Gieger

doi:10.1038/ng.467

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A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Journal article

Peer reviewed

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Nicole Soranzo, Tim D. Spector, Massimo Mangino, Brigitte Kuehnel, Augusto Rendon, Alexander Teumer, Christina Willenborg, Benjamin Wright, Li Chen, Mingyao Li, …

Nature genetics, Vol.41(11), pp.1182-U38

01/11/2009

DOI: https://doi.org/10.1038/ng.467

PMCID: PMC3108459

PMID: 19820697

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.

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Title: A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Creators - without role: Nicole Soranzo - King's College London
Tim D. Spector - King's College London
Massimo Mangino - King's College London
Brigitte Kuehnel - Helmholtz Zentrum München
Augusto Rendon - University of Cambridge
Alexander Teumer - University of Greifswald
Christina Willenborg - University of Lübeck
Benjamin Wright - University of Leicester
Li Chen - University of Ottawa
Mingyao Li - University of Pennsylvania
Perttu Salo - University of Helsinki
Benjamin F. Voight - Broad Institute
Philippa Burns - University of Cambridge
Roman A. Laskowski - European Bioinformatics Institute
Yali Xue - Wellcome Sanger Institute
Stephan Menzel - King's College London
David Altshuler - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
John R. Bradley - University of Cambridge
Suzannah Bumpstead - Wellcome Sanger Institute
Mary-Susan Burnett - MedStar Washington Hospital Center
Joseph Devaney - MedStar Washington Hospital Center
Angela Doering - Helmholtz Zentrum München
Roberto Elosua - College Station Medical Center
Stephen E. Epstein - MedStar Washington Hospital Center
Wendy Erber - Cambridge University Hospitals NHS Foundation Trust
Mario Falchi - Imperial College London
Stephen F. Garner - University of Cambridge
Mohammed J. R. Ghori - Wellcome Sanger Institute
Alison H. Goodall - University of Leicester
Rhian Gwilliam - Wellcome Sanger Institute
Hakon H. Hakonarson - Children's Hospital of Philadelphia
Alistair S. Hall - Leeds Gen Infirm, BHF Heart Res Ctr, Leeds, W Yorkshire, England
Naomi Hammond - Wellcome Sanger Institute
Christian Hengstenberg - University of Regensburg
Thomas Illig - Helmholtz Zentrum München
Inke R. Koenig - University of Lübeck
Christopher W. Knouff - GlaxoSmithKline
Ruth McPherson - University of Ottawa
Olle Melander - Lund University
Vincent Mooser - GlaxoSmithKline
Matthias Nauck - University of Greifswald
Markku S. Nieminen - Helsinki University Hospital
Christopher J. O'Donnell - Harvard University
Leena Peltonen - University of Helsinki
Simon C. Potter - Wellcome Sanger Institute
Holger Prokisch - Technical University of Munich
Daniel J. Rader - University of Pennsylvania
Catherine M. Rice - Wellcome Sanger Institute
Robert Roberts - University of Ottawa
Veikko Salomaa - University of Helsinki
Jennifer Sambrook - University of Cambridge
Stefan Schreiber - Kiel University
Heribert Schunkert - University of Lübeck
Stephen M. Schwartz - University of Washington
Jovana Serbanovic-Canic - University of Cambridge
Juha Sinisalo - Helsinki University Hospital
David S. Siscovick - University of Washington
Klaus Stark - University of Regensburg
Ida Surakka - University of Helsinki
Jonathan Stephens - University of Cambridge
John R. Thompson - University of Leicester
Uwe Voelker - University of Greifswald
Henry Voelzke - University of Greifswald
Nicholas A. Watkins - University of Cambridge
George A. Wells - University of Ottawa
H-Erich Wichmann - Ludwig-Maximilians-Universität München
David A. Van Heel - Queen Mary University of London
Chris Tyler-Smith - Wellcome Sanger Institute
Swee Lay Thein - King's College London
Sekar Kathiresan - Harvard University
Markus Perola - University of Helsinki
Muredach P. Reilly - University of Pennsylvania
Alexandre F. R. Stewart - University of Ottawa
Jeanette Erdmann - University of Lübeck
Nilesh J. Samani - University of Leicester
Christa Meisinger - Helmholtz Zentrum München
Andreas Greinacher - University of Greifswald
Panos Deloukas - Wellcome Sanger Institute
Willem H. Ouwehand - University of Cambridge
Christian Gieger - Helmholtz Zentrum München
Publication Details: Nature genetics, Vol.41(11), pp.1182-U38
Publisher: Springer Nature
Number of pages: 11
Grant note: German National Genome Research Network (NGFN) Leicester NIHR Biomedical Research Unit in Cardiovascular Disease National Institute for Health Research of England (NIHR) (TwinsUK); National Institutes of Health Research (NIHR) German Federal Ministry of Education and Research (BMBF); Federal Ministry of Education & Research (BMBF) MedSTAR Research Institute (PennCATH/MedSTAR) U54 RR020278 / National Center for Research Resource; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) Munich Center of Health Sciences (MC Health) (KORA) MOP82810; NA6650; MOP77682 / Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) Finnish Foundation for Cardiovascular Research, Sigrid Juselius Foundation (COROGENE); Sigrid Juselius Foundation LSHM-CT-2004-503485 / EU-FP6; European Commission Helmholtz Zentrum Munchen; Helmholtz Association US National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA G0000111 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Deutsche Forschungsgemeinschaft; German Research Foundation (DFG) SFB TR 19 / Deutsche Forschungsgemeinschaft; German Research Foundation (DFG) German Research Center for Environmental Health, Neuherberg, Germany NGFN-2 / German Federal Ministry of Education and Research (BMBF); Federal Ministry of Education & Research (BMBF) 11966 / Canada Foundation for Innovation and Ontario Research Foundation; Canada Foundation for Innovation 01ZZ9603; 01ZZ0103; 01ZZ0403; 03ZIK012 / Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) Federal State of Mecklenburg-West Pomerania (SHIP) Ministry of Cultural Affairs, Social Ministry of the Federal State of Mecklenburg-West Pomerania Siemens Healthcare, Erlangen, Germany; Siemens AG UKBS-CC1 / Wellcome Trust NIHR, CBMRC, NHSBT, (CBR); National Institutes of Health Research (NIHR) T1D / Juvenile Diabetes Research Foundation/Wellcome Trust; Juvenile Diabetes Research Foundation; Wellcome Trust G0000111 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) HEALTH-F2-2008-ENGAGE; QLG2-CT-2002-01254; LSHM-CT-2006-037593 / EU; European Commission GlaxoSmithKline National Heart, Lung, and Blood Institute (STAMPEED); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Cardiovascular Institute (University of Pennsylvania)
Identifiers: 9935280708331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article