Abstract
A nanocomposite consisting of cadmium oxide decorated with carbon nanotubes (CdO.CNT NC) was prepared by a wet-chemical technique, and its optical, morphological, and structural properties were characterized by FTIR, UV/Vis, FESEM coupled to XEDS, XPS, and XRD methods. A flat glassy carbon electrode was modified with the nanocomposite to obtain a sensor for L-glutathione (GSH) which displays improved sensitivity, a large dynamic range and good long-term stability. The calibration plot (best acquired at a voltage of 0.5 V) is linear (r (2) = 0.99) in the 0.1 nM to 0.01 M GSH concentration range. The detection limit is as low as 30.0 pM, and the sensitivity is similar to 9.49 mu Aai...mu M(-1)ai...cm(-2). To the best of our knowledge, this is the first report on the determination of GSH using such a modified glassy carbon electrode (GCE) in combination with I-V method. The GCE was applied to the selective determination of GSH in spiked rabbit serum samples and gave acceptable results.