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A microwave-mediated catalyst- and solvent-free regioselective Biginelli reaction in the synthesis of highly functionalized novel tetrahydropyrimidines
Journal article   Peer reviewed

A microwave-mediated catalyst- and solvent-free regioselective Biginelli reaction in the synthesis of highly functionalized novel tetrahydropyrimidines

Palani Sokkan Harikrishnan, Stephen Michael Rajesh, Subbu Perumal and Abdulrahman I. Almansour
Tetrahedron letters, Vol.54(9), pp.1076-1079
27/02/2013
DOI: https://doi.org/10.1016/j.tetlet.2012.12.034

Abstract

Biginelli reaction Catalyst-free Green chemistry Solvent-free Tetrahydropyrimidine
A series of novel ethyl 2-oxo/thio-4-aryl-6-(arylsulfonylmethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylates has been synthesized regioselectively by the Biginelli reaction of ethyl 3-oxo-4-(arylsulfonyl)butanoate, aromatic aldehyde and urea/thiourea under microwave irradiation and solvent- and catalyst-free conditions.

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