Abstract
A new Tetrahydrofuran sesquiterpene 7,10-Epoxy-10-methy-dodeca-1,6(14)-diene-3,4-diol (1) along with three known Tetrahydrofuran sesquiterpene compounds 2,6,10-trimethyl-2,5:7,10-dioxido-dodeca-3,11-dien-5-ol (2),cis-hydroxydavanone (3), and davana acid (4). All isolated metabolites were tested against MCF-7, HCT-116, and HepG-2 cancer cell lines. Compound2showed potent activity against MCF-7 (IC50= 26 +/- 0.4 mu g/ml), HCT-116 (IC50= 30.4 +/- 0.9 mu g/ml), and HepG-2 (IC50= 20.5 +/- 0.3 mu g/ml) cancer cells.