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A new cytotoxic guaianolide from Chrysanthemum boreale
Journal article

A new cytotoxic guaianolide from Chrysanthemum boreale

Ki Hun Park, Min Suk Yang, Moon Ki Park, Sang Chan Kim, Chae Ha Yang, Sook Jahr Park, Jong Rok Lee and Essam Hassan Ibrahim
Fitoterapia, Vol.80(1), pp.54-56
01/01/2009
DOI: https://doi.org/10.1016/j.fitote.2008.09.013
PMID: 18983901

Abstract

Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
A new cytotoxic guaianolide was isolated from Chrysanthemum boreale Makino. The structure of guaianolide was elucidated as 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide (1). Compound I exhibited cytotoxic activity (IC(50 <=)4 mu g/ml) against all five human cancer cell lines tested. (C) 2008 Elsevier B.V. All rights reserved.

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