Abstract
A new fatty alcohol (1) together with ten known compounds was isolated from the leaves of Terminalia arjuna Roxb. Their chemical structures were established on the basis of physical, chemical, and spectroscopic methods to be identified as (E)-3,5,7,16 tetramethylheptadeca-2-en-1-ol (1), apigenin, luteolin, vitexin, isovitexin, luteolin-3'-glucuronide, gallic acid, methyl gallate, ellagic acid, stigmasterol, and beta-sitosterol-3-O-glucoside. Apigenin, vitexin, and isovitexin were isolated for the first time from this species, while luteolin-3'-glucuronide was isolated for the first time from the genus Terminalia. Compound 1 and its acetate derivative (2) showed good antileishmanial activity with IC50 values of 9.0 and 2.0 mu g/mL, respectively.