Abstract
An efficient, one-pot, multi-component synthesis of 3-amino-2-arylimidazo[1,2-
a]pyridines, 3-amino-2-arylimidazo[1,2-
a]pyrazines, and 3-amino-2-arylimidazo[1,2-
a]pyrimidines is described. Heating a mixture of a 2-aminopyridine, 2-aminopyrazine or 2-aminopyrimidine, a benzaldehyde, and imidazoline-2,4,5-trione under solvent-free conditions afforded imine derivatives of the title compounds in excellent yields. Single-crystal X-ray analysis conclusively confirms the structure of these bridgehead bicyclic 5–6 heterocycles.
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