Abstract
Copper compounds are promising candidates for next-generation metal anticancer drugs. Therefore, we synthesized and characterized a formate bridged 1D coordination polymer ICu(L)(HCOO)(2)](n), (L = 2-methoxy-6-methyl-3-((quinolin-8-yliminolmethyl)chroman-4-ol), PCUI, wherein the Cu(s) center adopts a square pyramidal coordination environment with adjacent Cu center dot center dot center dot Cu distances of 5.28 angstrom. Primarily, in vitro DNA interaction studies revealed a metallopolymer which possesses high DNA binding propensity and cleaves DNA via the oxidative pathway. We further analysed its potential on cancerous cells MCF-7, HeLa, A549, and two non-tumorigenic cells HEK293 and HBE. The selective cytotoxicity potential of PCU1 against A549 cells driven us to examine the mechanistic pathways comprehensively by carrying out various assays viz, cell cycle arrest, Annexin V-FTIC/PI assay, autophagy, intercellular localization, mitochondrial membrane potential 'MMP', antiproliferative assay, and gene expression of TGF-beta and MMP-2.