Sign in
Back
A novel dilithiation approach to 3,4-dihydro-2H-1,3-benzothiazines, 3,4-Dihydro-2H-1,3-benzoxazines, and 2,3,4,5-tetrahydro-1,3-benzothiazepines
Journal article   Peer reviewed

A novel dilithiation approach to 3,4-dihydro-2H-1,3-benzothiazines, 3,4-Dihydro-2H-1,3-benzoxazines, and 2,3,4,5-tetrahydro-1,3-benzothiazepines

Alan R Katritzky, Yong-Jiang Xu and Ritu Jain
Journal of organic chemistry, Vol.67(23), pp.8234-8236
15/11/2002
DOI: https://doi.org/10.1021/jo020176e
PMID: 12423158

Abstract

Central Nervous System Agents - chemical synthesis Chemistry, Pharmaceutical Heterocyclic Compounds, 2-Ring - chemical synthesis Lithium - chemistry Oxazines - chemical synthesis Thiazepines - chemical synthesis Thiazines - chemical synthesis
3,4-Dihydro-2H-1,3-benzothiazines 4, 3,4-dihydro-2H-1,3-benzoxazines 9, and 2,3,4,5-tetrahydro-1,3-benzothiazepines 6 were synthesized by directed ortho-lithiation of thiophenols and phenols and by side-chain lithiation of substituted thiophenols, respectively, in one-pot by reacting with N,N-bis[(benzotriazol-1-yl)methyl]amines 3 as 1,3-biselectrophile synthons.

Metrics

1 Record Views

Details