Abstract
Aim: To detect CA- 125 level in saliva of oral cancer patients.
Methodology: A total of fifty-six SCC patients and thirty healthy subjects were selected. A non- stimulated whole saliva (5cc) was collected and evaluated for CA- 125 level ELISA.
Results: A higher salivary CA 125 level (514.2 +/- 132.6 U/mL) was observed in poorly differentiated SCC followed by moderately differentiated (340.6 +/- 80.2 U/mL) and minimum values was observed in well differentiated SCC (236.2 +/- 76.2 U/mL). The mean +/- SD CA- 125 level in group I patients was 428.5 +/- 110.2 U/mL and in group II was 132.4 +/- 58.6 U/mL. Higher salivary CA 125 level (520.5 +/- 168.4 U/mL) was observed in stage IV and minimum in stage 1 (165.2 +/- 46.2 U/mL) which was statistically significant (P< 0.05).
Conclusion: Patients with poorly differentiated SCC, cases of buccal mucosa and stage IV exhibited higher values of salivary CA- 125 level as compared to healthy control.