Abstract
•Modeling of racimic mixture taste of sucrose-caffeine on receptor nerves in humans.•Mixture taste sucrose-caffeine mixture on receptor nerves in humans is investigated.•Energitical characterization of sucrose-caffeine mixture taste on receptor nerves in humans.
This work represents a contribution in the comprehension of a racimic mixture of caffeine-sucrose molecules and their taste-taste interaction, by the use of a binary model expression of non-exclusive competitive extended Hill model. This extended model is deduced by statistical physics treatment. The simulation results suggested that the sucrose molecule formed an aggregate of two molecules and anchored with a non-parallel position onto the human neuroreceptor taste sites. Contrary to the sucrose molecule, the molecule of caffeine is anchored in a parallel position with the human neuroreceptor taste sites. The pore size distribution (PSD) and the adsorption energy distribution (AED) of human neuroreceptor sites are derived through the selected model to describe porosity and energitical homogeneity of taste adsorbent surface. So, the mutual interaction between molecules of racemic mixture dose-response curves of caffeine and sucrose on human neuroreceptor sites. Firstly, this model is used to analyze the taste-taste interaction mechanism of the mixture of bitter caffeine-sweet sucrose taste. Secondly, all these stereo and energetical parameters will be used for an objective description of the taste of the mixture of caffeine-sucrose molecules in the intense and qualitative aspects of the taste of the mixture.
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The concentration-psychophysical response curve for the detection of the caffeine-sucrose racemic mixture on (a) bitter and (b) sweet taste receptor nerves in humans and also the AED evolution of binding receptor energies.