Abstract
Philadelphia (Ph)-positive chromosome or Ph translocation has been recognized in 90–95 chronic myeloid leukemia (CML) cases worldwide. However, only 5–8% CML patients show complex variant translocations. In the present study, hematological tests for a 47-year-old female CML patient were performed to determine the hemoglobin, platelets and total leukocyte values. A FISH test was carried out to recognize the
BCR/ABL
gene fusion, and a cytogenetic analysis was performed. The hematological results showed an increase in WBC (414000/mm
3
) and a decrease in hemoglobin (8.9 mg/dl), indicating the anemic condition in the CML patient. Furthermore, cytogenetic karyotyping results showed 46,XX,t(6;9;22)(p21;q34;q11) and positive for Ph chromosome. In conclusion, in the present study, we report a rare three-way complex variant translocation in a CML patient.