Abstract
Dispiropyrrolidine analogues were synthesized and tested for their in vitro antimycobacterial activity. Compounds 5f showed an interesting activity against a strain of Mycobacterium tuberculosis H37Rv and INHR M. tuberculosis.
A series of dispiropyrrolothiazoles compounds were synthesized using 1,3-dipolar cycloaddition and were screened for antimycobacterial activity against Mycobacterium tuberculosis H37Rv and INH resistant M. tuberculosis strains. Two of them were showing good activity with MIC of less than 1μM. Compound (5f) was found to be the most active with MIC of 0.210 and 8.312μM respectively.