Abstract
In this study, an electrochemical sensor was fabricated for the non-enzymatic detection ofl-glutathioneviaan electrochemical approach using wet chemically prepared Co3O4-doped SnO(2)nanoparticles (NPs) decorated on a glassy carbon electrode (GCE). X-ray photoelectron spectroscopy (XPS), X-ray powder diffraction (XRD), field-emission scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDS), UV/visible spectroscopy, Brunauer-Emmett-Teller (BET) analysis, and Fourier-transform infrared (FTIR) spectroscopy were carried out for the detailed characterization of the synthesized NPs. The Co3O4-doped SnO(2)NPs were deposited onto a GCE, resulting in the proposedl-glutathione sensor, and it was calibratedviaplotting currentversusthe concentration ofl-glutathione. The sensor sensitivity (20.9873 mu A mu M(-1)cm(-2)) is obtained from the slope of the calibration plot, considering the surface area (0.0316 cm(2)) of active NPs on the GCE. In the non-enzymatic detection ofl-glutathione, the assembled sensor exhibits a broad linear dynamic range (0.1 mM-0.1 nM), a limit of detection (LOD) of 93.65 +/- 4.68 pM, a limit of quantification (LOQ) of 936.5 +/- 46.8 pM, appreciable reproducibility, outstanding working-electrode stability, and high efficiency. It is able to detectl-glutathione in real biological samples efficiently. Thus, this is an alternative approach for the reliable detection of chemicals and biochemicals in the environmental and healthcare sectors.