Abstract
Currently (March 2020) COVID-19 disease has recorded the most significant number of deaths and cases as compared to coronaviruses' types. Initially, the virus was referred to as 2019-nCoV. Subsequently, the International Committee on Taxonomy of Viruses (ICTV) named it the SARS-CoV-2 virus because it is significantly similar to the causative agent of (SARS-CoVs). All Nidovirales' viruses are positive-sense non-segmented and enveloped viruses. They have big genomes for the RNA viruses. Coronavirinae has the most significant documented RNA genomes, having around 30 kilobases (kb) of genomes. The critical di fferences in the families of Nidovirus are noted in the type, sizes, and the number of structural proteins. The variances cause substantial alterations in the morphology and structure of the viruses and nucleocapsids. Currently, the COVID-19 diseases have recorded the most significant number of deaths and cases as compared to other kinds of coronaviruses. In conclusion, since the outbreak of (COVID-19) disease in China, the illness is spreading very quickly across the globe. There was no evidence showing that the viruses were manufactured in laboratories or engineered till now. Extensive lab work on the mechanisms of infection and genetic factors such as polymorphism that may play an essential role in disease is needed urgently.