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A route to hydroxylfluorenes: TsOH-mediated condensation reactions of 1,3-diketones with propargylic alcohols
Journal article   Peer reviewed

A route to hydroxylfluorenes: TsOH-mediated condensation reactions of 1,3-diketones with propargylic alcohols

Liang-Feng Yao, Davin Tan, Xiaohe Miao and Kuo-Wei Huang
RSC advances, Vol.2(19), pp.7594-7598
01/01/2012

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
An efficient method of preparing hydroxylfluorenes by TsOH-mediated tandem alkylation/rearrangements of propargylic alcohols with 1,3-diketones is described. These reactions are accomplished in moderate to good yields under mild conditions to offer a straightforward and convenient one step synthetic route to hydroxylfluorene derivatives through a plausible mechanism involving a sequence of dehydration, addition, rearrangement and aromatization.

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