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A short stereoselective synthesis of (-)-chloramphenicol and (+)-thiamphenicol
Journal article   Peer reviewed

A short stereoselective synthesis of (-)-chloramphenicol and (+)-thiamphenicol

G Bhaskar, V S Kumar and B V Rao
Tetrahedron: asymmetry, Vol.15(8), pp.1279-1283
19/04/2004
DOI: https://doi.org/10.1016/j.tetasy.2004.03.007

Abstract

Chemistry Chemistry, Inorganic & Nuclear Chemistry, Organic Chemistry, Physical Physical Sciences Science & Technology
A common strategy for the synthesis of (-)-chloramphenicol and (+)-thiamphenicol is described. These antibiotics have been synthesized from commercially available 4-nitrobenzaldehyde and 4-(methylthio)benzaldehyde in three and four steps, respectively. (C) 2004 Elsevier Ltd. All rights reserved.

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