Abstract
The first catalytic asymmetric synthesis of tetrahydroxan then ones is presented. The simple organocatalytic enantioselective domino reactions between salicylic aldehyde derivatives and alpha,beta-unsaturated cyclic ketones proceed with excellent chemoselectivity to give the corresponding tetrahydroxanthenones in moderate to good yields and high enantioselectivities. (c) 2007 Elsevier Ltd. All rights reserved.