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A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N '-benzyl-N,N-dimethylureas
Journal article   Open access  Peer reviewed

A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N '-benzyl-N,N-dimethylureas

Keith Smith, Gamal A. El-Hiti, Amany S. Hegazy and Benson Kariuki
Beilstein journal of organic chemistry, Vol.7(1), pp.1219-1227
06/09/2011
DOI: https://doi.org/10.3762/bjoc.7.142
PMCID: 3182431
PMID: 21977206

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Lithiation of N'-benzyl-N,N-dimethylurea and its substituted derivatives with t-BuLi (3.3 equiv) in anhydrous THF at 0 degrees C followed by reaction with various electrophiles afforded a range of 3-substituted isoindolin-1-ones in high yields.
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https://doi.org/10.3762/bjoc.7.142View
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