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A simple and efficient synthesis of fused heterocyclic quinoline derivatives
Journal article   Peer reviewed

A simple and efficient synthesis of fused heterocyclic quinoline derivatives

Nariman M. Nahas and Ali A. Abdel Hafez
Heterocyclic communications, Vol.13(6), pp.381-386
01/01/2007

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
The reaction of arylidenemalononitrile 2a-e with 5-chloro-8-quinolinol 1 gave the corresponding pyrane derivatives 3a-e Their cyclization with acetic anhydride/pyridine, formamide, triethylorthoformate then with aniline, ethyl cyanoacetate, and nitrous acid afforded a series of poly cyclic heterocycles containing pyrimidine and triazine rings.

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