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A simple one-pot synthesis of quinoline-4-carboxylic acids by the Pfitzinger reaction of isatin with enaminones in water
Journal article   Peer reviewed

A simple one-pot synthesis of quinoline-4-carboxylic acids by the Pfitzinger reaction of isatin with enaminones in water

Ibrahim Elghamry and Yasair Al-Faiyz
Tetrahedron letters, Vol.57(1), pp.110-112
06/01/2016
DOI: https://doi.org/10.1016/j.tetlet.2015.11.070

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A simple one-pot method for synthesizing quinoline-4-carboxylic acids (3) by the reaction of enaminones (I) and isatin (2) using the Pfitzinger reaction conditions is described. Additionally, a plausible mechanism for this transformation is presented. (C) 2015 Elsevier Ltd. All rights reserved.

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