A simplified green chemistry approaches to synthesis of 2-substituted 1,2,3-triazoles and 4-amino-5-cyanopyrazole derivatives conventional heating versus microwave and ultrasound as ecofriendly energy sources

Khadijah M. Al-Zaydi

doi:10.1016/j.ultsonch.2009.02.007

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A simplified green chemistry approaches to synthesis of 2-substituted 1,2,3-triazoles and 4-amino-5-cyanopyrazole derivatives conventional heating versus microwave and ultrasound as ecofriendly energy sources

Journal article

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A simplified green chemistry approaches to synthesis of 2-substituted 1,2,3-triazoles and 4-amino-5-cyanopyrazole derivatives conventional heating versus microwave and ultrasound as ecofriendly energy sources

Khadijah M. Al-Zaydi

Ultrasonics sonochemistry, Vol.16(6), pp.805-809

01/08/2009

DOI: https://doi.org/10.1016/j.ultsonch.2009.02.007

PMID: 19345637

Abstract

1,2,3-Triazole

2-Arylhydrazonocyano acetamides

Ecofriendly energy sources

Green chemistry

Microwave irradiation

Pyrazol-4-amine

Triazolopyrimidine

Ultrasound irradiation

Cyanoacetamides 3 were prepared via reacting ethyl cyanoacetate with benzylamine. Yields and reaction times needed for reaction completion at room temperature, by microwaves ( μω) heating and under ultrasound (US) irradiations are compared. The formed cyanoacetamides were coupled with aromatic diazonium salts and the formed arylhydrazones were used as precursors to title triazoles and pyrazoles via reacting the former with hydroxylamine and chloroacetonitrile. Yields of products formed via conventional heating are compared with those of μω and US irradiation.

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Title: A simplified green chemistry approaches to synthesis of 2-substituted 1,2,3-triazoles and 4-amino-5-cyanopyrazole derivatives conventional heating versus microwave and ultrasound as ecofriendly energy sources
Creators - without role: Khadijah M. Al-Zaydi - Department of Chemistry, Girls' College of Education, King Abdul-Aziz University, P.O. Box 50918, Jeddah 21533, Kingdom of Saudi Arabia.
Publication Details: Ultrasonics sonochemistry, Vol.16(6), pp.805-809
Publisher: Elsevier B.V
Identifiers: 9933241908331
Academic Unit: University of Jeddah
Language: English
Resource Type: Journal article