Abstract
The structure activity relationship of 1-isopropylamino-3-(2'-substituted naphthoxy) propan-2-ois analogs, which are beta-adrenergic blocking drugs, is discussed. The blocking activity of these compounds is found to be dominantly controlled by electronic and steric factors. Significant correlations have been obtained between the blocking activity and negentropy, equalized eletronegativity and partial charge.