Abstract
A new efficient γ-lactams
4 synthesis was achieved by two successive reactions: alkylation of nitroalkane anions with dimethyl α-(bromomethyl) fumarate
1 leading to the formation of (
E)-1-alkyl-2,3-dimethoxycarbonyl butadienes
3a,
b resulting of tandem alkylation–elimination (dehydronitration) processes, followed by an intramolecular cyclization on addition of primary amine.
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