Abstract
The biflavanone (2
S,2
″S)-7,7″-di-
O-methyltetrahydroamentoflavone and five known flavonoids, 7-
O-methylnaringenin, 7,3′-
O-dimethylquercetin, 7-
O-methylapigenin, 7-
O-methylluteolin, and eriodictyol were isolated from the leaves of
Rhus retinorrhoea Steud, Ex Olive. The biflavanone exhibited moderate antimalarial activity with IC
50 0.98 μg/ml against
Plasmodium falciparum (W2 Clone) and weak activity against
P. falciparum (D6 Clone) with IC
50 2.8 μg/ml. Nevertheless, it did not display any cytotoxicity. 7-
O-Methylnaringenin showed weak antimicrobial activity against
Candida albicans, C. krusei, Staphylococcus aureus, Mycobacterium smegmatis, M. intracellulare, and M. xenopi with MIC∼ 100 μg/ml. Characterization of each compound was based on spectral analysis and comparison with reported data.
The biflavanone (2
S, 2″
S)-7,7″-di-
O-niethyltetrahydroamantoflavone exhibiting moderate antimalarial activity was isolated from
Rhus retinorrhoea.