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A106 HOST-PATHOGEN INTERACTIONS: Toll-Like Receptor-Induced Epithelial Antiviral Resistance Affects The Early Influenza Viral Cycle With An Associated Upregulation In Ifitm1 And Ifitm2
Journal article   Peer reviewed

A106 HOST-PATHOGEN INTERACTIONS: Toll-Like Receptor-Induced Epithelial Antiviral Resistance Affects The Early Influenza Viral Cycle With An Associated Upregulation In Ifitm1 And Ifitm2

M Leiva-Juarez, V Kulkarni, Y Wang, S Bupapanapadu, S Batres and S Wali
American journal of respiratory and critical care medicine, Vol.195
01/01/2017

Abstract

Antiviral drugs Infections Influenza Ligands Protein expression
Viral entry and nuclear translocation was measured by immunofluorescence staining at different time points and imaged by confocal microscopy. Conclusions: Inducible antiviral resistance in lung epithelial cells following treatment with TLR2/6 and TLR9 ligands occurs early in the viral cycle and is associated with increased levels of IFITM2 and IFITM3.

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