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AAS determination of bromhexine, flunarizine and ranitidine hydrochlorides in pharmaceutical formulations
Journal article   Peer reviewed

AAS determination of bromhexine, flunarizine and ranitidine hydrochlorides in pharmaceutical formulations

S Khalil, S A Ibrahim, F I Zedan and M S Abd-El-monem
Chemia analityczna, Vol.50(5), pp.897-904
01/01/2005

Abstract

Chemistry Chemistry, Analytical Physical Sciences Science & Technology
A new AAS method for the determination of bromhexine(Bx), flunarizine (Fn) and ranitidine (Rn) hydrochlorides in pure solutions and pharmaceutical preparations has been proposed. Ion associates of the above drugs with [Cd(SCN)(4)](2-) and / or [Co(NO2)(6)](3-) were precipitated and the excess of complex anion was determined. Applying the proposed method, Bx, Fn and Rn could be determined in the concentration ranges: 1.5-15.08, 1.62-16.25 and 1.26-12.61 mu g mL(-1), respectively.

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