ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma

Monisha E. Nongpiur; Chiea Chuen Khor; Hongyan Jia; Belinda K. Cornes; Li-Jia Chen; Chunyan Qiao; K. Saidas Nair; Ching-Yu Cheng; Liang Xu; Ronnie George; Tan Do; Khaled Abu-Amero; Shamira A. Perera; Mineo Ozaki; Takanori Mizoguchi; Yasuo Kurimoto; Sancy Low; Liza-Sharmini A. Tajudin; Ching-Lin Ho; Clement C. Y. Tham; Ileana Soto; Paul T. K. Chew; Hon-Tym Wong; Balekudaru Shantha; Masako Kuroda; Essam A. Osman; Guangxian Tang; Sujie Fan; Hailin Meng; Hua Wang; Bo Feng; Victor H. K. Yong; Serena M. L. Ting; Yang Li; Ya-Xing Wang; Zheng Li; Raghavan Lavanya; Ren-Yi Wu; Ying-Feng Zheng; Daniel H. Su; Seng-Chee Loon; R. Rand Allingham; Michael A. Hauser; Nagaswamy Soumittra; Vedam L. Ramprasad; Naushin Waseem; Azhany Yaakub; Kee-Seng Chia; Govindasamy Kumaramanickavel; Tina T. Wong; Alicia C. How; Tran Nguyen Bich Chau; Cameron P. Simmons; Jin-Xin Bei; Yi-Xin Zeng; Shomi S. Bhattacharya; Mingzhi Zhang; Donald T. Tan; Yik-Ying Teo; Saleh A. Al-Obeidan; Do Nhu Hon; E-Shyong Tai; Seang-Mei Saw; Paul J. Foster; Lingam Vijaya; Jost B. Jonas; Tien-Yin Wong; Simon W. M. John; Chi-Pui Pang; Eranga N. Vithana; Ningli Wang; Tin Aung

doi:10.1371/journal.pgen.1004089

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ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma

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ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma

Monisha E. Nongpiur, Chiea Chuen Khor, Hongyan Jia, Belinda K. Cornes, Li-Jia Chen, Chunyan Qiao, K. Saidas Nair, Ching-Yu Cheng, Liang Xu, Ronnie George, …

PLoS genetics, Vol.10(3), pp.e1004089-e1004089

01/03/2014

DOI: https://doi.org/10.1371/journal.pgen.1004089

PMCID: PMC3945113

PMID: 24603532

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size = -0.045 mm, P = 8.17x10(-9)). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45x10(-9); 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions.

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Title: ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma
Creators - without role: Monisha E. Nongpiur - Singapore National Eye Center
Chiea Chuen Khor - Genome Institute of Singapore
Hongyan Jia - Beijing Tongren Hospital
Belinda K. Cornes - Singapore National Eye Center
Li-Jia Chen - Chinese University of Hong Kong
Chunyan Qiao - Beijing Tongren Hospital
K. Saidas Nair - Jackson Laboratory
Ching-Yu Cheng - National University Health System
Liang Xu - Beijing Tongren Hospital
Ronnie George - Sankara Nethralaya
Tan Do - Vietnam Natl Inst Ophthalmol, Hanoi, Vietnam
Khaled Abu-Amero - King Saud University
Shamira A. Perera - Singapore Eye Research Institute
Mineo Ozaki - Miyata Eye Hospital
Takanori Mizoguchi - Akebono Clinic
Yasuo Kurimoto - Kobe Gen Hosp, Kobe, Hyogo, Japan
Sancy Low - Moorfields Eye Hospital
Liza-Sharmini A. Tajudin - Supreme Council Of Health
Ching-Lin Ho - Singapore National Eye Center
Clement C. Y. Tham - Chinese University of Hong Kong
Ileana Soto - Jackson Laboratory
Paul T. K. Chew - Natl Univ Hlth Syst, Dept Ophthalmol, Singapore, Singapore
Hon-Tym Wong - Tan Tock Seng Hospital
Balekudaru Shantha - Sankara Nethralaya
Masako Kuroda - Kobe Gen Hosp, Kobe, Hyogo, Japan
Essam A. Osman - King Saud University
Guangxian Tang - Hebei Eye Hospital
Sujie Fan - Han Dan City Eye Hospital - The Third Hospital of Handan
Hailin Meng - Anyang Eye Hosp, Anyang, Peoples R China
Hua Wang - Beijing Tongren Hospital
Bo Feng - Beijing Tongren Hospital
Victor H. K. Yong - Singapore National Eye Center
Serena M. L. Ting - Singapore National Eye Center
Yang Li - Capital University
Ya-Xing Wang - Capital University
Zheng Li - Singapore National Eye Center
Raghavan Lavanya - Singapore National Eye Center
Ren-Yi Wu - Singapore Eye Research Institute
Ying-Feng Zheng - Singapore Eye Research Institute
Daniel H. Su - Singapore National Eye Center
Seng-Chee Loon - National University Health System
R. Rand Allingham - Duke Medical Center
Michael A. Hauser - Duke Medical Center
Nagaswamy Soumittra - Sankara Nethralaya
Vedam L. Ramprasad - Sankara Nethralaya
Naushin Waseem - Moorfields Eye Hospital
Azhany Yaakub - Hospital Universiti Sains Malaysia
Kee-Seng Chia - National University of Singapore
Govindasamy Kumaramanickavel - Sankara Nethralaya
Tina T. Wong - Singapore National Eye Center
Alicia C. How - Singapore National Eye Center
Tran Nguyen Bich Chau - Oxford University Clinical Research Unit
Cameron P. Simmons - Nuffield Orthopaedic Centre
Jin-Xin Bei - Sun Yat-sen University Cancer Center
Yi-Xin Zeng - Southern Medical University
Shomi S. Bhattacharya - Moorfields Eye Hosp, NIHR Biomed Res Ctr Ophthalmol, London, England
Mingzhi Zhang - Chinese University of Hong Kong
Donald T. Tan - National University Health System
Yik-Ying Teo - National University Health System
Saleh A. Al-Obeidan - King Saud University
Do Nhu Hon - National Hospital of Pediatrics
E-Shyong Tai - National University Health System
Seang-Mei Saw - Singapore Eye Research Institute
Paul J. Foster - Moorfields Eye Hospital
Lingam Vijaya - Sankara Nethralaya
Jost B. Jonas - Heidelberg University
Tien-Yin Wong - National University Health System
Simon W. M. John - Howard Hughes Medical Institute
Chi-Pui Pang - Chinese University of Hong Kong
Eranga N. Vithana - Singapore Eye Research Institute
Ningli Wang - College Station Medical Center
Tin Aung - Singapore Eye Research Institute
Publication Details: PLoS genetics, Vol.10(3), pp.e1004089-e1004089
Publisher: Public Library Science
Number of pages: 8
Grant note: BMRC 09/1/35/19/616; 08/1/35/19/550 / Biomedical Research Council, Singapore; Agency for Science Technology & Research (A*STAR) 81030016 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) International Glaucoma Association Genome Institute of Singapore NMRC/TCR/002-SERI/2008 (R626/47/2008TCR); CSA R613/34/2008; NMRC 0796/2003; STaR/0003/2008 / National Medical Research Council, Singapore; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Richard Desmond Charitable Trust via Fight for Sight R01EY011721 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) National Research Foundation of Singapore; National Research Foundation, Singapore 1001/PPSP/812101 / USM Research University 7102036; 7081001 / Beijing Municipal Natural Science Foundation; Beijing Natural Science Foundation
Identifiers: 9948225908331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article