Abstract
The ligated stomach of the rat was used to study the net fluxes of acid and fluoride. Luminal 10 mM NaF decreased basal and histamine-stimulated acid secretion (-53%), but increased four times the loss of acid from the gastric lumen filled with 100 mM HCI. Two hours intravenous infusion of 5 mM NaF alone (20 mu moles F-.Kg(-1).h(-1)) did not affect acid secretion, but the addition of 0.1 mM AIF(3) to the infused solution stimulated acid secretion (+28%).
The stimulation of acid secretion by histamine did not change absorption of fluoride. When the luminal concentration of acid was increased with 100 mM HCI, fluoride absorption was enhanced by 80% as compared with control. The increase of fluoride absorption was accompanied by a rise of fluoride concentration in the plasma (+43% - +53%). A positive correlation was observed between the percentage absorption of fluoride and its concentration in the plasma.