Abstract
A SARS-CoV-2 virus-specific reverse transcriptase-polymerase chain reaction (RT-PCR) test is usually used to diagnose COVID-19. However, this test requires up to 2 days for completion. Moreover, to avoid false-negative outcomes, serial testing may be essential. The availability of RT-PCR test kits is currently limited, highlighting the need for alternative approaches for the precise and rapid diagnosis of COVID-19. Patients suspected to be infected with SARS-CoV-2 can be assessed using chest CT scan images. However, CT images alone cannot be used for ruling out SARS-CoV-2 infection because individual patients may exhibit normal radiological results in the primary phases of the disease. A machine learning (ML)-based recognition and segmentation system was developed to spontaneously discover and compute infection areas in CT scans of COVID-19 patients. The computable assessment exhibited suitable performance for automatic infection region allocation. The ML models developed were suitable for the direct detection of COVID-19 (+). ML was confirmed to be a complementary diagnostic technique for diagnosing COVID-19(+) by forefront medical specialists. The complete manual delineation of COVID-19 often requires up to 225.5 min; however, the proposed RILML method decreases the delineation time to 7 min after four iterations of model updating.