Abstract
Improving the understanding of ALS pathogenesis is crucial in developing earlier diagnostic approaches in addition to proposing new effective treatments. Thus, this review will provide the most recent research studies related to pathogenesis, diagnostic examinations, and treatments. We performed a computerized search using electronic databases; MEDLINE, EMBASE, and google scholar, through November, 2017. Search strategies used following MeSH terms in searching via these databases: "Amyotrophic lateral sclerosis", "diagnosis", "screening", "management", "therapy". Unfortunately, ALS is considered an incurable disease, with an anticipated life expectancy of 3- 5 years after the onset of symptoms. Amyotrophic lateral sclerosis is a devastating neurodegenerative problem that typically begins with focal muscle weakness and ultimately progresses to death from respiratory failing. Although there is no cure for ALS, therapy could enhance both the quality and length of life. Care of ALS patients is best given by multidisciplinary ALS centers along with family physicians. It is important to continue nutritional research studies in order to give better care to ALS patients, as some evidence has shown they could help to alleviate the effect of the disease on their daily lives. Present discoveries of the underlying mechanism of ALS have helped to reduce the progression of the illness. Thus, the future treatments need to aim toward preventing neuronal damage, as patients progress from their initial start.